IL-10 is required for development of protective Th1 responses in IL-12-deficient mice upon Candida albicans infection.

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Article

IL-10 is required for development of protective Th1 responses in IL-12-deficient mice upon Candida albicans infection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1998

Mencacci A, Cenci E, Del Sero G, Fé d'Ostiani C, Mosci P, Trinchieri G, Adorini L, Romani L

Abstract excerpt

IL-12 is both required and prognostic for Th1 development in mice with Candida albicans infection. To delineate further the physiologic role of IL-12 in antifungal immunity, mice deficient for this cytokine were assessed for susceptibility to C. albicans infections, and for parameters of innate a...

Topics

Abatacept
Animals
Antigens, CD
Antigens, Differentiation
B7-2 Antigen
CTLA-4 Antigen
Candidiasis
Female
Genetic Predisposition to Disease
Immunity, Innate
Immunoconjugates
Interleukin-10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-12

Interleukin-4

Male

Membrane Glycoproteins

Mice

Mice, Inbred BALB C

Source

Open in PubMed

Identifiers

PMID: 9834110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9834110-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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