Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IL-10 is required for development of protective Th1 responses in IL-12-deficient mice upon Candida albicans infection.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1998

Mencacci A, Cenci E, Del Sero G, Fé d'Ostiani C, Mosci P, Trinchieri G, Adorini L, Romani L

Abstract excerpt

IL-12 is both required and prognostic for Th1 development in mice with Candida albicans infection. To delineate further the physiologic role of IL-12 in antifungal immunity, mice deficient for this cytokine were assessed for susceptibility to C. albicans infections, and for parameters of innate and adaptive immunity. IL-12-deficient mice were highly susceptible to gastrointestinal infection or to reinfection and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Antigens, Differentiation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Immunity, Innate

Share to Interleukin-4

Share to Membrane Glycoproteins

Share to Mice, Inbred BALB C

Source

Identifiers

PMID: 9834110

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IL-10 is required for development of protective Th1 responses in IL-12-deficient mice upon Candida albicans infection.PMID 9834110Read ↗

IL-12 and Related Cytokines: Function and Regulatory Implications in<i>Candida albicans</i>InfectionSemantic proximity Read ↗

The Role of the IL-12 Cytokine Family in Directing T-Cell Responses in Oral CandidosisSemantic proximity Read ↗

IL‐22 in antifungal immunitySemantic proximity Read ↗

Dectin-1 isoforms contribute to distinct Th1/Th17 cell activation in mucosal candidiasis.Semantic proximity Read ↗

Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection.Semantic proximity Read ↗

Interleukin-12 but not interferon-gamma production correlates with induction of T helper type-1 phenotype in murine candidiasis.Semantic proximity Read ↗

IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice.Semantic proximity Read ↗

Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells.Semantic proximity Read ↗

B Cell Recognition of Candida albicans Hyphae via TLR 2 Promotes IgG1 and IL-6 Secretion for TH17 Differentiation.Semantic proximity Read ↗

Dectin-1 is required for beta-glucan recognition and control of fungal infection.Semantic proximity Read ↗

Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development.Semantic proximity Read ↗

Lack of both types 1 and 2 cytokines, tissue inflammatory responses, and immune protection during pulmonary infection by Mycobacterium bovis bacille Calmette-Guérin in IL-12-deficient mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.