Article
Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2004
Netea Mihai G, Sutmuller Roger, Hermann Corinna, Van der Graaf Chantal A A, Van der Meer Jos W M, van Krieken Johan H, Hartung Thomas, Adema Gosse, Kullberg Bart Jan
Abstract excerpt
Toll-like receptor (TLR) 2 and TLR4 play a pivotal role in recognition of Candida albicans. We demonstrate that TLR2(-/-) mice are more resistant to disseminated Candida infection, and this is associated with increased chemotaxis and enhanced candidacidal capacity of TLR2(-/-) macrophages. Although production of the proinflammatory cytokines TNF, IL-1alpha, and IL-1beta is normal, IL-10 release is severely...
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