Article
Recombinant mapping of the familial hyperinsulinism gene to an 0.8 cM region on chromosome 11p15.1 and demonstration of a founder effect in Ashkenazi Jews.
Human molecular genetics - 1 May 1995
Glaser B, Chiu K C, Liu L, Anker R, Nestorowicz A, Cox N J, Landau H, Kaiser N, Thornton P S, Stanley C A
Abstract excerpt
A gene for autosomal recessive familial hyperinsulinism (HI) (OMIM: 256450), a neonatal metabolic disease characterized by inappropriate insulin secretion in the presence of severe hypoglycemia, was recently mapped to a 6.6 cM interval between the markers D11S926 and D11S928 on chromosome 11p in...
Topics
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Female
- Founder Effect
- Genes, Recessive
- Genetic Linkage
- Genetic Markers
- Haplotypes
- Humans
- Hyperinsulinism
- Jews
- Male
- Pedigree
- Polymorphism, Genetic