Article
Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus.
Science (New York, N.Y.) - 21 Jun 1996
Morahan G, Huang D, Tait B D, Colman P G, Harrison L C
Abstract excerpt
Insulin-dependent diabetes mellitus (IDDM) is a multigenic autoimmune disease. An IDDM susceptibility gene was mapped to chromosome 2q34. This gene may act early in diabetogenesis, because "preclinical" individuals also showed linkage. Human leukocyte antigen (HLA)-disparate, but not HLA-identica...
Topics
- Alleles
- Animals
- Autoantibodies
- Chromosome Mapping
- Chromosomes, Human, Pair 2
- Diabetes Mellitus, Type 1
- Female
- Gene Frequency
- Genetic Linkage
- Genetic Markers
- Genetic Predisposition to Disease
- HLA Antigens
- Humans
- Insulin-Like Growth Factor Binding Protein 2
- Insulin-Like Growth Factor Binding Protein 5
- Islets of Langerhans
- Male
- Mice