Article
Analysis of centrosome abnormalities and angiogenesis in epidermal-targeted p53172H mutant and p53-knockout mice after chemical carcinogenesis: evidence for a gain of function.
Molecular carcinogenesis - 1 Nov 1998
Wang X J, Greenhalgh D A, Jiang A, He D, Zhong L, Brinkley B R, Roop D R
Abstract excerpt
We previously developed a transgenic mouse model that expresses in the epidermis a murine p53172R-->H mutant (p53m) under the control of a human keratin-1-based vector (HK1.p53m). In contrast to mice with wild-type p53 and p53-knockout mice, HK1.p53m mice exhibit increased susceptibility to chemi...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- Carcinogens
- Centrosome
- Disease Progression
- Endothelial Growth Factors
- Genes, p53
- Humans
- Lymphokines
- Mice
- Mice, Knockout
- Neovascularization, Pathologic
- Papilloma
- Phenotype
- Point Mutation