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Article

VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam.

Molecular biology of the cell - 1 Apr 2002

Lampugnani Maria Grazia, Zanetti Adriana, Breviario Ferruccio, Balconi Giovanna, Orsenigo Fabrizio, Corada Monica, Spagnuolo Raffaella, Betson Martha, Braga Vania, Dejana Elisabetta

Abstract excerpt

Previously published reports support the concept that, besides promoting homotypic intercellular adhesion, cadherins may transfer intracellular signals. However, the signaling pathways triggered by cadherin clustering and their biological significance are still poorly understood. We report herein that transfection of VE-cadherin (VEC) cDNA in VEC null endothelial cells induces actin rearrangement and increases...

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Identifiers

PMID: 11950930
DOI: 10.1091/mbc.01-07-0368
PMCID: PMC102260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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