Article
Distinct Rho GTPase activities regulate epithelial cell localization of the adhesion molecule CEACAM1: involvement of the CEACAM1 transmembrane domain.
Molecular and cellular biology - 1 Oct 2003
Fournès Bénédicte, Farrah Jennifer, Olson Melanie, Lamarche-Vane Nathalie, Beauchemin Nicole
Abstract excerpt
CEACAM1 is an intercellular adhesion glycoprotein. As CEACAM1 plays an important role in epithelial cell signaling and functions, we have examined its localization in epithelial cells. We have observed that distribution at cell contacts is not always seen in these cells, suggesting that CEACAM1 localization might be regulated. In Swiss 3T3 cells, the targeting of CEACAM1 at cell-cell boundaries is regulated by...
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