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Prognostic Implications of MDM2 and CDK4 Co-amplification in Liposarcoma: Insights from FISH analysis for Translational Oncology

16 Jul 2025

Abstract excerpt

PURPOSE: MDM2 and CDK4 amplifications are well-established diagnostic markers in liposarcoma, but the clinical relevance of their co-amplification remains underexplored. This study evaluates their amplification characteristics and combined prognostic impact to inform risk stratification and patient management. METHODS: Fluorescence in situ hybridisation (FISH) was performed on formalin-fixed paraffin-embedded...

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PMID: 40665169
DOI: 10.1007/s12094-025-03989-9

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