Article
MDM2 gene amplification in bone and soft-tissue tumors: association with tumor progression in differentiated adipose-tissue tumors.
International journal of cancer - 20 Oct 1995
Nakayama T, Toguchida J, Wadayama B, Kanoe H, Kotoura Y, Sasaki M S
Abstract excerpt
We have studied 107 bone and soft-tissue sarcomas and 8 lipomas for amplification of the MDM2 gene. This gene was amplified in 3 out of 67 osteosarcomas, 3 out of 20 malignant fibrous histiocytomas, 4 out of 20 liposarcomas, and 4 out of 8 lipomas. The amplification was associated with overexpres...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Blotting, Northern
- Bone Neoplasms
- Cell Differentiation
- Disease Progression
- Female
- Gene Amplification
- Genes, p53
- Histiocytoma, Benign Fibrous
- Humans
- Lipoma
- Liposarcoma
- Male
- Middle Aged
- Mutation