Article
Comprehensive mapping of p53 pathway alterations reveals an apparent role for both SNP309 and MDM2 amplification in sarcomagenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2011
Ito Moriko, Barys Louise, O'Reilly Terence, Young Sophie, Gorbatcheva Bella, Monahan John, Zumstein-Mecker Sabine, Choong Peter F, Dickinson Ian, Crowe Philip, Hemmings Christine, Desai Jayesh, Thomas David M, Lisztwan Joanna
Abstract excerpt
PURPOSE: Reactivation of p53 tumor suppressor activity in diseases such as soft-tissue sarcoma is considered an attractive means of targeted therapy. By systematically assessing alterations affecting the p53 pathway, we aimed to (a) classify sarcoma subtypes, (b) define a potential role in malignancy, and (c) identify potential patient biomarkers in this heterogeneous disease. EXPERIMENTAL DESIGN: We have mapped...
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