Article
Ocular pathology in mice with a transgenic insertion at the microphthalmia locus.
Journal of submicroscopic cytology and pathology - 1 Jul 1993
Boissy R E, Boissy Y L, Krakowsky J M, Lamoreux M L, Lingrel J B, Nordlund J J
Abstract excerpt
A DNA insertional mutation at the microphthalmia locus (mi) in a transgenic mouse has been developed and given the allele symbol of mitg (Krakowsky et al., 1993). Mice homozygous for this transgene have eyes markedly reduced in size and relatively unpigmented. In this study, we examined the morphology of these eyes using light and electron microscopy. Transgenic homozygous (mitg/mitg) animals have a structurally...
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