Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of melanoma in TPras transgenic mice.

Carcinogenesis - 1 Sept 1999

Broome Powell M, Gause P R, Hyman P, Gregus J, Lluria-Prevatt M, Nagle R, Bowden G T

Abstract excerpt

In order to study the oncogenesis of melanocytes, transgenic mouse lines were established that express a mutated human Ha-ras (TPras) gene in pigment producing cells. The ras transgenic mice exhibit an altered phenotype, including melanocytic hyperplasia and a muted agouti coat, indicative of hyperproliferative melanocytes. These mice and their wild-type littermates have been subjected to a variety of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 9,10-Dimethyl-1,2-benzanthracene
Share to Albinism
Share to Hair Color

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Monophenol Monooxygenase

Share to Neoplasms, Radiation-Induced

Share to Papilloma

Share to Skin Pigmentation

Share to Tetradecanoylphorbol Acetate

Source

Identifiers

PMID: 10469620
DOI: 10.1093/carcin/20.9.1747

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of melanoma in TPras transgenic mice.PMID 10469620Read ↗

Hyperpigmentation and melanocytic hyperplasia in transgenic mice expressing the human T24 HA‐ras gene regulated by a mouse tyrosinase promoterSemantic proximity Read ↗

Carcinogen treatment in mouse selectively expressing activated N-Ras Q61K in melanocytes recapitulates metastatic cutaneous melanoma development.Semantic proximity Read ↗

Pigmented uveal tumours in a transgenic mouse model.Semantic proximity Read ↗

Chemically induced forestomach papillomas in transgenic mice carry mutant human c-Ha-ras transgenes.Semantic proximity Read ↗

UV exposure, genetic targets in melanocytic tumors and transgenic mouse models.Semantic proximity Read ↗

Metastasizing Melanoma Formation Caused by Expression of Activated N-RasQ61K on an INK4a-Deficient BackgroundSemantic proximity Read ↗

Rapid induction of skin and mammary tumors in human c-Ha-ras proto-oncogene transgenic rats by treatment with 7,12-dimethylbenz[a]anthracene followed by 12-O-tetradecanoylphorbol 13-acetate.Semantic proximity Read ↗

Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice.Semantic proximity Read ↗

Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis.Semantic proximity Read ↗

Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice.Semantic proximity Read ↗

Non-melanoma skin cancer in mouse and man.Semantic proximity Read ↗

Transgenic mice provide genetic evidence that transforming growth factor alpha promotes skin tumorigenesis via H-ras-dependent and H-ras-independent pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.