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Article

Functional analysis of myosin mutations that cause familial hypertrophic cardiomyopathy.

Biophysical journal - 1 Dec 1998

Roopnarine O, Leinwand L A

Abstract excerpt

We have studied the actin-activated ATPase activities of three mutations in the motor domain of the myosin heavy chain that cause familial hypertrophic cardiomyopathy. We placed these mutations in rodent alpha-cardiac myosin to establish the relevance of using rodent systems for studying the biochemical mechanisms of the human disease. We also wished to determine whether the biochemical defects in these mutant...

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Identifiers

PMID: 9826622
DOI: 10.1016/S0006-3495(98)77743-4
PMCID: PMC1299973

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