Functional analysis of myosin mutations that cause familial hypertrophic cardiomyopathy.

doi:10.1016/S0006-3495(98)77743-4

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Article

Functional analysis of myosin mutations that cause familial hypertrophic cardiomyopathy.

Biophysical journal - 1 Dec 1998

Roopnarine O, Leinwand L A

Abstract excerpt

We have studied the actin-activated ATPase activities of three mutations in the motor domain of the myosin heavy chain that cause familial hypertrophic cardiomyopathy. We placed these mutations in rodent alpha-cardiac myosin to establish the relevance of using rodent systems for studying the bioc...

Topics

Actins
Adenosine Triphosphatases
Adenosine Triphosphate
Alleles
Animals
Binding Sites
Biomechanical Phenomena
Biophysical Phenomena
Biophysics
COS Cells
Cardiomyopathy, Hypertrophic
Chickens
Humans
Models, Molecular
Molecular Motor Proteins
Mutation
Myosin Heavy Chains
Myosins

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