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Article

Skeletal muscle expression and abnormal function of beta-myosin in hypertrophic cardiomyopathy.

The Journal of clinical investigation - 1 Jun 1993

Cuda G, Fananapazir L, Zhu W S, Sellers J R, Epstein N D

Abstract excerpt

Hypertrophic cardiomyopathy is an important inherited disease. The phenotype has been linked, in some kindreds, to the beta-myosin heavy chain (beta-MHC) gene. Missense and silent mutations in the beta-MHC gene were used as markers to demonstrate the expression of mutant and normal cardiac beta-MHC gene message in skeletal muscle of hypertrophic cardiomyopathy patients. Mutant beta-myosin, also shown to be...

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Identifiers

PMID: 8514894
DOI: 10.1172/JCI116530
PMCID: PMC443355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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