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Article

Altered myocyte contractility and calcium homeostasis in alpha-myosin heavy chain point mutations linked to familial dilated cardiomyopathy.

Archives of biochemistry and biophysics - 1 Feb 2017

Klos Matthew, Mundada Lakshmi, Banerjee Indroneal, Morgenstern Sherry, Myers Stephanie, Leone Michael, Kleid Mark, Herron Todd, Devaney Eric

Abstract excerpt

Mutations in the human cardiac motor protein beta-myosin heavy chain (βMHC) have been long recognized as a cause of familial hypertrophic cardiomyopathy. Recently, mutations (P830L and A1004S) in the less abundant but faster isoform alpha-myosin heavy chain (αMHC) have been linked to dilated cardiomyopathy (DCM). In this study, we sought to determine the cellular contractile phenotype associated with these point...

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Source

Identifiers

PMID: 28088328
DOI: 10.1016/j.abb.2016.12.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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