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Article

Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule.

Biophysical journal - 1 Dec 1998

Penzotti J L, Fozzard H A, Lipkind G M, Dudley S C

Abstract excerpt

The marine guanidinium toxins, saxitoxin (STX) and tetrodotoxin (TTX), have played crucial roles in the study of voltage-gated Na+ channels. Because they have similar actions, sizes, and functional groups, they have been thought to associate with the channel in the same manner, and early mutational studies supported this idea. Recent experiments by. Biophys. J. 67:2305-2315) have suggested that the toxins bind...

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Identifiers

PMID: 9826589
DOI: 10.1016/S0006-3495(98)77710-0
PMCID: PMC1299940

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