Article
Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule.
Biophysical journal - 1 Dec 1998
Penzotti J L, Fozzard H A, Lipkind G M, Dudley S C
Abstract excerpt
The marine guanidinium toxins, saxitoxin (STX) and tetrodotoxin (TTX), have played crucial roles in the study of voltage-gated Na+ channels. Because they have similar actions, sizes, and functional groups, they have been thought to associate with the channel in the same manner, and early mutation...
Topics
- Adult
- Animals
- Binding Sites
- Biophysical Phenomena
- Biophysics
- Female
- Humans
- In Vitro Techniques
- Kinetics
- Models, Molecular
- Muscle, Skeletal
- Mutagenesis, Site-Directed
- Mutation
- Oocytes
- Recombinant Proteins
- Saxitoxin
- Sodium Channels
- Tetrodotoxin