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Article

Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels.

Channels (Austin, Tex.) - 1 Jan 2000

Zhang Min-Min, McArthur Jeff R, Azam Layla, Bulaj Grzegorz, Olivera Baldomero M, French Robert J, Yoshikami Doju

Abstract excerpt

Tetrodotoxin (TTX) is the quintessential ligand of voltage-gated sodium channels (NaVs). Like TTX, mu-conotoxin peptides are pore blockers, and both toxins have helped to define the properties of neurotoxin receptor Site 1 of NaVs. Here, we report unexpected results showing that the recently discovered mu-conotoxin KIIIA and TTX can simultaneously bind to Site 1 and act in concert. Results with saturating...

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Identifiers

PMID: 19221510
DOI: 10.4161/chan.3.1.7500
PMCID: PMC2878737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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