[The role of CD95 (APO-1/Fas) mutations in lymphoproliferative and malignant lymphatic diseases].

doi:10.1055/s-2008-1043871

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Article

[The role of CD95 (APO-1/Fas) mutations in lymphoproliferative and malignant lymphatic diseases].

Klinische Padiatrie - 1 Jan 2000

Beltinger C, Böhler T, Schrappe M, Ludwig W D, Debatin K M

Abstract excerpt

CD95 (APO-1/Fas)-mediated apoptosis plays a major role in normal lymphocyte regulation. CD95 mutations cause a benign autoimmune lymphoproliferation syndrome (ALPS) in mice and humans. CD95 is mutated in some de novo T-lineage acute lymphoblastic leukemia of childhood and these mutations might be...

Topics

Animals
Apoptosis
Autoimmune Diseases
B-Lymphocytes
Child
Humans
Lymphoma
Lymphoproliferative Disorders
Mice
Multiple Myeloma
Mutation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
T-Lymphocytes
fas Receptor

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