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Article

Impaired regulation of neuronal nitric oxide synthase and heart rate during exercise in mice lacking one nNOS allele.

The Journal of physiology - 1 Aug 2004

Danson E J F, Mankia K S, Golding S, Dawson T, Everatt L, Cai S, Channon K M, Paterson D J

Abstract excerpt

We tested the hypothesis that a single allele deletion of neuronal nitric oxide synthase (nNOS) would impair the neural control of heart rate following physical training, and that this phenotype could be restored following targeted gene transfer of nNOS. Voluntary wheel-running (+EX) in heterozygous nNOS knockout mice (nNOS(+/-), +EX; n= 52; peak performance 9.1 +/- 1.8 km day(-1)) was undertaken and compared to...

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Identifiers

PMID: 15155789
DOI: 10.1113/jphysiol.2004.062299
PMCID: PMC1665015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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