Article
Hippocampal N-acetyl aspartate in unaffected siblings of patients with schizophrenia: a possible intermediate neurobiological phenotype.
Biological psychiatry - 15 Nov 1998
Callicott J H, Egan M F, Bertolino A, Mattay V S, Langheim F J, Frank J A, Weinberger D R
Abstract excerpt
BACKGROUND: Shared neurobiological characteristics of patients with schizophrenia and their siblings may represent "intermediate phenotypes" that may more closely reflect the genetic susceptibility underlying this illness. We sought evidence of such phenotypes using magnetic resonance spectroscop...
Topics
- Adult
- Aspartic Acid
- Biomarkers
- Choline
- Creatine
- Family
- Female
- Hippocampus
- Humans
- Magnetic Resonance Imaging
- Male
- Phenotype
- Phosphocreatine
- Prefrontal Cortex
- Risk
- Schizophrenia