Article
Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia.
The American journal of psychiatry - 1 Apr 2003
Callicott Joseph H, Egan Michael F, Mattay Venkata S, Bertolino Alessandro, Bone Ashley D, Verchinksi Beth, Weinberger Daniel R
Abstract excerpt
OBJECTIVE: The identification of neurobiological intermediate phenotypes may hasten the search for susceptibility genes in complex psychiatric disorders such as schizophrenia. Earlier family studies have suggested that deficits in executive cognition and working memory may be related to genetic susceptibility for schizophrenia, but the biological basis for this behavioral phenotype has not been identified....
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