Role of connexin (gap junction) genes in cell growth control: approach with site-directed mutagenesis and dominant-negative effects.

doi:10.1016/s0378-4274(98)00056-3

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Article

Role of connexin (gap junction) genes in cell growth control: approach with site-directed mutagenesis and dominant-negative effects.

Toxicology letters - 1 Aug 1998

Omori Y, Duflot-Dancer A, Mesnil M, Yamasaki H

Abstract excerpt

Evidence is accumulating that connexin (Cx) genes form a family of tumor-suppressor genes. Our long-standing study revealed that, in almost all tumors, some abnormality in gap junction is observed, including loss or reduction of expression, aberrant localization of gap junction. In this study, we...

Topics

Animals
Cell Division
Connexin 26
Connexins
Gap Junctions
Genes, Dominant
Genes, Tumor Suppressor
Glioma
Humans
Mice
Mice, Knockout
Mutagenesis, Site-Directed
Mutation
Tumor Cells, Cultured

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