Article
Genetic and epigenetic changes of intercellular communication genes during multistage carcinogenesis.
Cancer detection and prevention - 1 Jan 1999
Yamasaki H, Omori Y, Zaidan-Dagli M L, Mironov N, Mesnil M, Krutovskikh V
Abstract excerpt
During multistage carcinogenesis, the functions of several key genes involved in cell growth control must be damaged. Such genes include not only those involved in cell cycle control of individual cells, but also those involved in the coordination of cell growth throughout a given tissue through cell-cell communication. The most intimate form of intercellular communication is mediated by gap junctions. Gap...
Topics
- Animals
- Cell Communication
- Connexins
- Gap Junctions
- Genes, Tumor Suppressor
- Humans
- Mice
- Multigene Family
- Mutation
- Neoplasms
- Rats