Article
Germ line, stem cells, and epigenetic reprogramming.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 2008
Surani M A, Durcova-Hills G, Hajkova P, Hayashi K, Tee W W
Abstract excerpt
The germ cell lineage has the unique attribute of generating the totipotent state. Development of blastocysts from the totipotent zygote results in the establishment of pluripotent primitive ectoderm cells in the inner cell mass of blastocysts, which subsequently develop into epiblast cells in postimplantation embryos. The germ cell lineage in mice originates from these pluripotent epiblast cells of...
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