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Article

Cbfb/Runx1 repression-independent blockage of differentiation and accumulation of Csf2rb-expressing cells by Cbfb-MYH11.

Blood - 18 Feb 2010

Hyde R Katherine, Kamikubo Yasuhiko, Anderson Stacie, Kirby Martha, Alemu Lemlem, Zhao Ling, Liu P Paul

Abstract excerpt

It is known that CBFB-MYH11, the fusion gene generated by inversion of chromosome 16 in human acute myeloid leukemia, is causative for oncogenic transformation. However, the mechanism by which CBFB-MYH11 initiates leukemogenesis is not clear. Previously published reports showed that CBFB-MYH11 dominantly inhibits RUNX1 and CBFB, and such inhibition has been suggested as the mechanism for leukemogenesis. Here we...

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Topics

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Share to Core Binding Factor Alpha 2 Subunit
Share to GATA2 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Hematopoiesis

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Share to Interleukin-1 Receptor-Like 1 Protein

Share to Oncogene Proteins, Fusion

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Source

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Identifiers

PMID: 20007544
DOI: 10.1182/blood-2009-06-227413
PMCID: PMC2826765

Genes

MYH11
CBFB
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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Research trail→

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Cbfb/Runx1 repression-independent blockage of differentiation and accumulation of Csf2rb-expressing cells by Cbfb-MYH11.PMID 20007544Read ↗

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