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Double-Stranded RNA Binding by Human Cytomegalovirus pTRS1

26 May 2005

Abstract excerpt

The human cytomegalovirus (HCMV) TRS1 and IRS1 genes rescue replication of vaccinia virus (VV) that has a deletion of the double-stranded RNA binding protein gene E3L (VVDeltaE3L). Like E3L, these HCMV genes block the activation of key interferon-induced, double-stranded RNA (dsRNA)-activated antiviral pathways. We investigated the hypothesis that the products of these HCMV genes act by binding to dsRNA. pTRS1...

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PMID: 15919885
DOI: 10.1128/jvi.79.12.7311-7318.2005

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