Double-stranded RNA-dependent protein kinase (PKR) is regulated by reovirus structural proteins.

doi:10.1006/viro.1997.8664

Back to search

Article

Double-stranded RNA-dependent protein kinase (PKR) is regulated by reovirus structural proteins.

Virology - 4 Aug 1997

Yue Z, Shatkin A J

Abstract excerpt

Reovirus sigma3 is a virion outer shell protein that also binds dsRNA and stimulates translation by blocking activation of the dsRNA-dependent protein kinase, PKR. Purified sigma3 was shown by gel shift assay to bind specifically to RNA duplexes of minimal length 32-45 base pairs. PKR binding to...

Topics

Animals
COS Cells
Enzyme Activation
HeLa Cells
Humans
Mutation
Protein Serine-Threonine Kinases
RNA, Double-Stranded
RNA, Viral
Reoviridae
Viral Structural Proteins
eIF-2 Kinase

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.