[Pathogenesis of disorder due to thyroid hormone receptor mutation].

Article

[Pathogenesis of disorder due to thyroid hormone receptor mutation].

Rinsho byori. The Japanese journal of clinical pathology - 1 Oct 1998

Nagaya T, Seo H

Abstract excerpt

Thyroid hormone action is mediated through its nuclear receptor (thyroid hormone receptor; TR). A mutation in the TR causes resistance to thyroid hormone (RTH) with autosomal dominant inheritance. Using T3 binding assay, gel shift assay and transfection study, the pathogenesis of this disorder wa...

Topics

Humans
Mutation
Receptors, Thyroid Hormone
Thyroid Diseases

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