New insights on the mechanism(s) of the dominant negative effect of mutant thyroid hormone receptor in generalized resistance to thyroid hormone.

doi:10.1172/JCI116058

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Article

New insights on the mechanism(s) of the dominant negative effect of mutant thyroid hormone receptor in generalized resistance to thyroid hormone.

The Journal of clinical investigation - 1 Nov 1992

Yen P M, Sugawara A, Refetoff S, Chin W W

Abstract excerpt

Generalized resistance to thyroid hormone (GRTH) is a syndrome of hyposensitivity to triiodothyronine (T3) that displays autosomal dominant inheritance. The genetic defect commonly lies in the ligand-binding domain of one of the TR beta alleles. Since there are two major thyroid hormone receptor...

Topics

Animals
DNA
Drug Resistance
Mutation
Rats
Receptors, Thyroid Hormone
Triiodothyronine

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