[Thyroid hormone receptors and the disorders].

Abstract excerpt

Thyroid hormone is essential for normal development and several metabolic pathways. Its action is mediated through its nuclear receptors (thyroid hormone receptors: TRs), which regulate gene transcriptions in a ligand-dependent manner. The abnormality of TR functions is linked with several disorders including resistance to thyroid hormone (RTH), malignancy and euthyroid sick syndrome. For example, mutant TRs were...

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