ras gene mutations as a prognostic marker in adenocarcinoma of the human lung without lymph node metastasis.

Abstract excerpt

Adenocarcinoma of the lung obtained at surgical resection was examined for mutation at codons 12, 13, and 61 of the oncogenes K-ras, H-ras, and N-ras, using polymerase chain reaction and oligonucleotide hybridization techniques. The mutation was detected in 18 of the 115 cases (15.7%), and 15 of 18 were at codon 12, 2 were at codon 13 of K-ras, and 1 was at codon 61 of N-ras. G to T transversions were most...

Topics

• Adenocarcinoma
• Adult
• Aged
• Aged, 80 and over
• Base Sequence
• Codon
• Female