Article
ras gene mutations as a prognostic marker in adenocarcinoma of the human lung without lymph node metastasis.
Cancer research - 15 May 1992
Sugio K, Ishida T, Yokoyama H, Inoue T, Sugimachi K, Sasazuki T
Abstract excerpt
Adenocarcinoma of the lung obtained at surgical resection was examined for mutation at codons 12, 13, and 61 of the oncogenes K-ras, H-ras, and N-ras, using polymerase chain reaction and oligonucleotide hybridization techniques. The mutation was detected in 18 of the 115 cases (15.7%), and 15 of...
Topics
- Adenocarcinoma
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Codon
- Female
- Genes, ras
- Humans
- Lung Neoplasms
- Lymphatic Metastasis
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Polymerase Chain Reaction
- Prognosis