Article
Apoptosis loss and bcl-2 expression: key determinants of lymph node metastases in T1 breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 1996
Sierra A, Castellsagué X, Tórtola S, Escobedo A, Lloveras B, Peinado M A, Moreno A, Fabra A
Abstract excerpt
The Bcl-2 proto-oncogene extends cell survival but does not confer any proliferative advantage to cells that express it. Thus, the loss of apoptosis may have a role in progression allowing the acquisition of additional mutations. To determine whether apoptosis loss at diagnosis is associated with...
Topics
- Adult
- Aged
- Apoptosis
- Biomarkers, Tumor
- Breast Neoplasms
- Cell Division
- Female
- Humans
- Immunohistochemistry
- Lymphatic Metastasis
- Middle Aged
- Mutation
- Neoplasm Invasiveness
- Proto-Oncogene Mas
- Proto-Oncogene Proteins c-bcl-2
- Tumor Suppressor Protein p53