Article
Apoptosis loss and bcl-2 expression: key determinants of lymph node metastases in T1 breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 1996
Sierra A, Castellsagué X, Tórtola S, Escobedo A, Lloveras B, Peinado M A, Moreno A, Fabra A
Abstract excerpt
The Bcl-2 proto-oncogene extends cell survival but does not confer any proliferative advantage to cells that express it. Thus, the loss of apoptosis may have a role in progression allowing the acquisition of additional mutations. To determine whether apoptosis loss at diagnosis is associated with the metastatic advantage of ductal breast carcinomas and to examine the relationship between Bcl-2 expression, p53,...
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