Article
Lipid lowering promotes accumulation of mature smooth muscle cells expressing smooth muscle myosin heavy chain isoforms in rabbit atheroma.
Circulation research - 16 Nov 1998
Aikawa M, Rabkin E, Voglic S J, Shing H, Nagai R, Schoen F J, Libby P
Abstract excerpt
Smooth muscle cells (SMCs) in the atherosclerotic intima characteristically differ from those in the arterial media, for example, by reduced expression of SMC differentiation/maturation markers such as smooth muscle myosin heavy chain isoforms (SM1 and SM2). This study tested the hypothesis that...
Topics
- Actin Cytoskeleton
- Animals
- Arteriosclerosis
- Becaplermin
- Cell Division
- Collagenases
- Gene Expression Regulation, Enzymologic
- Hypercholesterolemia
- Isomerism
- Lipids
- Male
- Matrix Metalloproteinase 3
- Matrix Metalloproteinase 9
- Microscopy, Electron
- Muscle, Smooth, Vascular