Article
Smoothelin is an indicator of reversible phenotype modulation of smooth muscle cells in balloon-injured rat carotid arteries.
Basic research in cardiology - 1 Jan 2002
Bär Harald, Wende P, Watson L, Denger S, van Eys G, Kreuzer J, Jahn L
Abstract excerpt
Restenosis is the major obstacle interfering with a successful long-term outcome of balloon angioplasty. Neointima formation following endothelial injury is the result of phenotype modulation and proliferation of smooth muscle cells (SMC). To characterize these time-dependent changes, a rat balloon injury model of carotid artery restenosis was assessed. We applied monoclonal antibodies recognizing desmin,...
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