Article
Phenotypic features of smooth muscle cells during the evolution of experimental carotid artery intimal thickening. Biochemical and morphologic studies.
Laboratory investigation; a journal of technical methods and pathology - 1 Oct 1991
Kocher O, Gabbiani F, Gabbiani G, Reidy M A, Cokay M S, Peters H, Hüttner I
Abstract excerpt
Balloon catheter denudation of rat carotid artery that results in significant medial damage is followed by marked intimal smooth muscle cell (SMC) proliferation associated with limited endothelial regrowth. In this report we demonstrate that: (a) SMC of the carotid media, preceding their intimal proliferation, develop a cytoskeletal profile and morphology consistent with a de-differentiated SMC phenotype; and (b)...
Topics
- Actins
- Animals
- Carotid Arteries
- Catheterization
- Cell Differentiation
- Cell Division
- Desmin
- Electrophoresis, Polyacrylamide Gel
- Endothelium, Vascular
- Male