Target discrimination by RNA-binding proteins: role of the ancillary protein U2A' and a critical leucine residue in differentiating the RNA-binding specificity of spliceosomal proteins U1A and U2B".

doi:10.1017/s1355838298981171

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Article

Target discrimination by RNA-binding proteins: role of the ancillary protein U2A' and a critical leucine residue in differentiating the RNA-binding specificity of spliceosomal proteins U1A and U2B".

RNA (New York, N.Y.) - 1 Nov 1998

Rimmele M E, Belasco J G

Abstract excerpt

The spliceosomal proteins U1A and U2B" each use a homologous RRM domain to bind specifically to their respective snRNA targets, U1hpll and U2hpIV, two stem-loops that are similar yet distinct in sequence. Previous studies have shown that binding of U2B" to U2hpIV is facilitated by the ancillary p...

Topics

Amino Acid Sequence
Autoantigens
Base Sequence
Binding Sites
Electrophoresis, Polyacrylamide Gel
Humans
Leucine
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Small Nuclear

RNA-Binding Proteins

Recombinant Fusion Proteins

Ribonucleoprotein, U1 Small Nuclear

Ribonucleoprotein, U2 Small Nuclear

Ribonucleoproteins, Small Nuclear

Spliceosomes

Source

Open in PubMed Open full text

Identifiers

PMID: 9814759
DOI: 10.1017/s1355838298981171
PMCID: PMC1369711

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9814759-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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