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Article

U1 small nuclear RNA variants differentially form ribonucleoprotein particles in vitro.

Gene - 25 Apr 2014

Somarelli Jason A, Mesa Annia, Rodriguez Carol E, Sharma Shalini, Herrera Rene J

Abstract excerpt

The U1 small nuclear (sn)RNA participates in splicing of pre-mRNAs by recognizing and binding to 5' splice sites at exon/intron boundaries. U1 snRNAs associate with 5' splice sites in the form of ribonucleoprotein particles (snRNPs) that are comprised of the U1 snRNA and 10 core components, including U1A, U1-70K, U1C and the 'Smith antigen', or Sm, heptamer. The U1 snRNA is highly conserved across a wide range of...

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Identifiers

PMID: 24583175
DOI: 10.1016/j.gene.2014.02.054
PMCID: PMC3997572

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Source receipt: pubmed, retrieved 7 Sept 2026.

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