Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rescue of the Epstein-Barr virus BZLF1 mutant, Z(S186A), early gene activation defect by the BRLF1 gene product.

Virology - 10 Nov 1998

Adamson A L, Kenney S C

Abstract excerpt

Expression of the Epstein-Barr virus (EBV) immediate-early protein, BZLF1 (Z), is sufficient to disrupt viral latency. Z transcriptionally activates the EBV early genes by binding to upstream Z-responsive elements (ZREs). Recently, a serine-to-alanine mutation of Z residue 186 (within the basic DNA binding domain) was shown to inhibit the ability of Z to induce lytic infection in latently infected cells, although...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Blotting, Western
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Promoter Regions, Genetic

Share to Transcription Factors

Share to Transfection

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 9813214
DOI: 10.1006/viro.1998.9396

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rescue of the Epstein-Barr virus BZLF1 mutant, Z(S186A), early gene activation defect by the BRLF1 gene product.PMID 9813214Read ↗

BZLF1 activation of the methylated form of the BRLF1 immediate-early promoter is regulated by BZLF1 residue 186.Semantic proximity Read ↗

ZEB1 regulates the latent-lytic switch in infection by Epstein-Barr virus.Semantic proximity Read ↗

Identification of a novel element involved in regulation of the lytic switch BZLF1 gene promoter of Epstein-Barr virus.Semantic proximity Read ↗

Mutant Cellular AP-1 Proteins Promote Expression of a Subset of Epstein-Barr Virus Late Genes in the Absence of Lytic Viral DNA Replication.Semantic proximity Read ↗

Shutoff of BZLF1 gene expression is necessary for immortalization of primary B cells by Epstein-Barr virus.Semantic proximity Read ↗

ZEB Negatively Regulates the Lytic-Switch BZLF1 Gene Promoter of Epstein-Barr VirusSemantic proximity Read ↗

Latency of Epstein-Barr virus is disrupted by gain-of-function mutant cellular AP-1 proteins that preferentially bind methylated DNA.Semantic proximity Read ↗

The Epstein-Barr virus lytic program is controlled by the co-operative functions of two transactivators.Semantic proximity Read ↗

Essential Role of Rta in Lytic DNA Replication of Epstein-Barr VirusSemantic proximity Read ↗

The B-Cell-Specific Transcription Factor and Master Regulator Pax5 Promotes Epstein-Barr Virus Latency by Negatively Regulating the Viral Immediate Early Protein BZLF1Semantic proximity Read ↗

Characterization of the Epstein-Barr virus BZLF1 protein transactivation domainSemantic proximity Read ↗

Functional and physical interactions between the Epstein-Barr virus (EBV) proteins BZLF1 and BMRF1: Effects on EBV transcription and lytic replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.