Article
Rescue of the Epstein-Barr virus BZLF1 mutant, Z(S186A), early gene activation defect by the BRLF1 gene product.
Virology - 10 Nov 1998
Adamson A L, Kenney S C
Abstract excerpt
Expression of the Epstein-Barr virus (EBV) immediate-early protein, BZLF1 (Z), is sufficient to disrupt viral latency. Z transcriptionally activates the EBV early genes by binding to upstream Z-responsive elements (ZREs). Recently, a serine-to-alanine mutation of Z residue 186 (within the basic D...
Topics
- Antigens, Viral
- Binding Sites
- Blotting, Western
- Burkitt Lymphoma
- DNA-Binding Proteins
- Gene Expression Regulation, Viral
- HeLa Cells
- Herpesvirus 4, Human
- Humans
- Immediate-Early Proteins
- Mutation
- Promoter Regions, Genetic
- Response Elements
- Trans-Activators
- Transcription Factors
- Transcriptional Activation
- Transfection
- Tumor Cells, Cultured