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Article

Shutoff of BZLF1 gene expression is necessary for immortalization of primary B cells by Epstein-Barr virus.

Journal of virology - 1 Aug 2012

Yu Xianming, McCarthy Patrick J, Wang Zhenxun, Gorlen Daniel A, Mertz Janet E

Abstract excerpt

The BZLF1 gene controls the switch between latent and lytic infection by Epstein-Barr virus (EBV). We previously reported that both the ZV and ZIIR elements within the BZLF1 promoter, Zp, are potent transcription silencers within the context of an intact EBV genome. We report here identification...

Read the complete abstract on PubMed

Topics

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Share to Antigens, Viral
Share to B-Lymphocytes
Share to Cell Transformation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epstein-Barr Virus Infections

Share to Gene Expression Regulation, Viral

Share to Herpesvirus 4, Human

Share to Silencer Elements, Transcriptional

Share to Virus Latency

Source

Open in PubMed Open full text

Identifiers

PMID: 22623769
DOI: 10.1128/JVI.00234-12
PMCID: PMC3421699

Genes

ZEB1
ZEB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22623769-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Shutoff of BZLF1 gene expression is necessary for immortalization of primary B cells by Epstein-Barr virus.PMID 22623769Read ↗

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Identification of a novel element involved in regulation of the lytic switch BZLF1 gene promoter of Epstein-Barr virus.Semantic proximity Read ↗

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The BHLF1 Locus of Epstein-Barr Virus Contributes to Viral Latency and B-Cell ImmortalizationSemantic proximity Read ↗

The B-Cell-Specific Transcription Factor and Master Regulator Pax5 Promotes Epstein-Barr Virus Latency by Negatively Regulating the Viral Immediate Early Protein BZLF1Semantic proximity Read ↗

Epstein–Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expressionSemantic proximity Read ↗

Identification of a negative cis element within the ZII domain of the Epstein-Barr virus lytic switch BZLF1 gene promoter.Semantic proximity Read ↗

Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 geneSemantic proximity Read ↗

AP-1 homolog BZLF1 of Epstein–Barr virus has two essential functions dependent on the epigenetic state of the viral genomeSemantic proximity Read ↗

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