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Essential Role of Rta in Lytic DNA Replication of Epstein-Barr Virus

18 Oct 2012

Abstract excerpt

Two transcription factors, ZEBRA and Rta, switch Epstein-Barr virus (EBV) from the latent to the lytic state. While ZEBRA also plays an obligatory role as an activator of replication, it is not known whether Rta is directly required for replication. Rta is dispensable for amplification of an oriLyt-containing plasmid in a transient-replication assay. Here, we assessed the requirement for Rta in activation of...

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PMID: 23077295
DOI: 10.1128/jvi.01995-12

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Essential Role of Rta in Lytic DNA Replication of Epstein-Barr VirusPMID 23077295Read ↗

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