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Article

The Epstein-Barr virus lytic program is controlled by the co-operative functions of two transactivators.

The EMBO journal - 15 Jun 2000

Feederle R, Kost M, Baumann M, Janz A, Drouet E, Hammerschmidt W, Delecluse H J

Abstract excerpt

The propagation of herpesviruses has long been viewed as a temporally regulated sequential process that results from the consecutive expression of specific viral transactivators. As a key step in this process, lytic viral DNA replication is considered as a checkpoint that controls the expression of the late structural viral genes. In a novel genetic approach, we show that both hypotheses do not hold true for the...

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Identifiers

PMID: 10856251
DOI: 10.1093/emboj/19.12.3080
PMCID: PMC203345

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Source receipt: pubmed, retrieved 7 Sept 2026.

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