Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BZLF1 activation of the methylated form of the BRLF1 immediate-early promoter is regulated by BZLF1 residue 186.

Journal of virology - 1 Jun 2005

Bhende Prasanna M, Seaman William T, Delecluse Henri-Jacques, Kenney Shannon C

Abstract excerpt

The Epstein-Barr virus (EBV) genome is highly methylated in latently infected cells. We recently reported that the EBV immediate-early (IE) protein BZLF1 (Z) preferentially binds to and activates transcription from the methylated form of the BRLF1 IE gene promoter (Rp). We now report that serine residue 186 in the Z DNA-binding domain plays an important role in the ability of Z to bind to and activate methylated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Viral
Share to Herpesvirus 4, Human

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immediate-Early Proteins

Share to Methylation

Share to Promoter Regions, Genetic

Share to Trans-Activators

Share to Viral Proteins

Share to Virus Latency

Source

Open in PubMed Open full text

Identifiers

PMID: 15919888
DOI: 10.1128/JVI.79.12.7338-7348.2005
PMCID: PMC1143640

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BZLF1 activation of the methylated form of the BRLF1 immediate-early promoter is regulated by BZLF1 residue 186.PMID 15919888Read ↗

Rescue of the Epstein-Barr virus BZLF1 mutant, Z(S186A), early gene activation defect by the BRLF1 gene product.Semantic proximity Read ↗

ZEB1 regulates the latent-lytic switch in infection by Epstein-Barr virus.Semantic proximity Read ↗

Latency of Epstein-Barr virus is disrupted by gain-of-function mutant cellular AP-1 proteins that preferentially bind methylated DNA.Semantic proximity Read ↗

Functional and physical interactions between the Epstein-Barr virus (EBV) proteins BZLF1 and BMRF1: Effects on EBV transcription and lytic replication.Semantic proximity Read ↗

Mutant Cellular AP-1 Proteins Promote Expression of a Subset of Epstein-Barr Virus Late Genes in the Absence of Lytic Viral DNA Replication.Semantic proximity Read ↗

Identification of a novel element involved in regulation of the lytic switch BZLF1 gene promoter of Epstein-Barr virus.Semantic proximity Read ↗

Identification of a negative cis element within the ZII domain of the Epstein-Barr virus lytic switch BZLF1 gene promoter.Semantic proximity Read ↗

Phosphorylation of Epstein-Barr virus ZEBRA protein at its casein kinase 2 sites mediates its ability to repress activation of a viral lytic cycle late gene by Rta.Semantic proximity Read ↗

Shutoff of BZLF1 gene expression is necessary for immortalization of primary B cells by Epstein-Barr virus.Semantic proximity Read ↗

Structure and function of the Epstein-Barr virus BZLF1 protein.Semantic proximity Read ↗

Amino acids in the basic domain of Epstein-Barr virus ZEBRA protein play distinct roles in DNA binding, activation of early lytic gene expression, and promotion of viral DNA replication.Semantic proximity Read ↗

Epstein-Barr virus transcription activator R upregulates BARF1 expression by direct binding to its promoter, independent of methylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.