Leptin controls bone formation through a hypothalamic relay.

Abstract excerpt

Menopause favors osteoporosis and obesity protects from it. In an attempt to decipher the molecular bases of these two well-known clinical observations, we hypothesized that they meant that bone remodeling, body weight, and reproduction are controlled by identical endocrine pathways. We used mouse genetics as a tool to translate these clinical observations into a molecular hypothesis. The ob/ob and db/db mice...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Body Weight
• Share to Bone and Bones
• Share to Bone Development