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Article

A novel substrate for analyzing Alzheimer's disease gamma-secretase.

FEBS letters - 25 Jun 1999

Lichtenthaler S F, Multhaup G, Masters C L, Beyreuther K

Abstract excerpt

Proteolytic processing of Alzheimer's disease amyloid precursor protein (APP) by beta-secretase leads to A4CT (C99), which is further cleaved by the as yet unknown protease called gamma-secretase. To study the enzymatic properties of gamma-secretase independently of beta-secretase, A4CT together...

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Share to Amyloid beta-Protein Precursor
Share to Amyloid Precursor Protein Secretases
Share to Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peptide Fragments

Share to Protein Processing, Post-Translational

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Source

Identifiers

PMID: 10405162
DOI: 10.1016/s0014-5793(99)00730-9

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10405162-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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