Article
Pharmacological inactivation of the endothelin type A receptor in the early chick embryo: a model of mispatterning of the branchial arch derivatives.
Development (Cambridge, England) - 1 Dec 1998
Kempf H, Linares C, Corvol P, Gasc J M
Abstract excerpt
In the present study, we have applied an antagonist treatment to the chick embryo in ovo in order to demonstrate and dissect the essential roles of the endothelin type A (ETA) receptor in the embryonic development. We have cloned, sequenced and expressed the cDNA of the chick ETA receptor and sho...
Topics
- Amino Acid Sequence
- Animals
- Bosentan
- Branchial Region
- COS Cells
- Cardiovascular System
- Chick Embryo
- Cloning, Molecular
- Craniofacial Abnormalities
- Embryo, Nonmammalian
- Embryonic Development
- Endothelin Receptor Antagonists
- Endothelins
- In Situ Hybridization
- Molecular Sequence Data
- Morphogenesis
- Phenotype
- Pyrimidines