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Article

Pristane-induced arthritis in mice. III. Lymphocyte phenotypic and functional abnormalities precede the development of pristane-induced arthritis.

Cellular immunology - 1 Nov 1991

Wooley P H, Whalen J D

Abstract excerpt

Pristane injection caused mediastinal lymphadenopathy in arthritis-susceptible DBA/1 mice, but not in arthritis-resistant DBA/2 mice. Early DBA/1 mediastinal lymph node changes were characterized by the accumulation of surface Ig+ cells and a CD8+ (Lyt 2) lymphocyte population, causing an inversion of the CD4/CD8 ratio. Depressed mitogen responses and the appearance of a nonspecific suppressor cell population...

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Identifiers

PMID: 1833075
DOI: 10.1016/0008-8749(91)90150-a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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