Article
Meta- and pooled analysis of GSTT1 and lung cancer: a HuGE-GSEC review.
American journal of epidemiology - 1 Dec 2006
Raimondi S, Paracchini V, Autrup H, Barros-Dios J M, Benhamou S, Boffetta P, Cote M L, Dialyna I A, Dolzan V, Filiberti R, Garte S, Hirvonen A, Husgafvel-Pursiainen K, Imyanitov E N, Kalina I, Kang D, Kiyohara C, Kohno T, Kremers P, Lan Q, London S, Povey A C, Rannug A, Reszka E, Risch A, Romkes M, Schneider J, Seow A, Shields P G, Sobti R C, Sørensen M, Spinola M, Spitz M R, Strange R C, Stücker I, Sugimura H, To-Figueras J, Tokudome S, Yang P, Yuan J-M, Warholm M, Taioli E
Abstract excerpt
Lung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.