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AIOLOS Variants Causing Immunodeficiency in Human and Mice

4 Apr 2022

Abstract excerpt

AIOLOS is encoded by IKZF3 and is a member of the IKAROS zinc finger transcription factor family. Heterozygous missense variants in the second zinc finger of AIOLOS have recently been reported to be found in the families of patients with inborn errors of immunity. The AIOLOSG159R variant was identified in patients with B-lymphopenia and familial Epstein–Barr virus-associated lymphoma. Early B-cell progenitors...

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Identifiers

PMID: 35444653
DOI: 10.3389/fimmu.2022.866582

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