Article
Impact of Prol2Ala variant in the peroxisome proliferator-activated receptor (PPAR) gamma2 on obesity and insulin resistance in Japanese Type 2 diabetic and healthy subjects.
Osaka city medical journal - 1 Jun 2002
Kawasaki Isao, Tahara Hideki, Emoto Masanori, Shoji Tetsuo, Shioji Atsushi, Okuno Yasuhisa, Inaba Masaaki, Nishizawa Yoshiki
Abstract excerpt
The peroxisome proliferator-activated receptor (PPAR) gamma is an important regulator of adipocyte differentiation and a modulator of intracellular insulin-signaling events. We examined the roles of the Pro12Ala variant of PPAR gamma2 in obesity and insulin resistance in 402 Japanese patients with type 2 diabetes and 116 control subjects. Among the diabetes subjects, the Pro12Pro homozygotes showed significantly...
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