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Article

The association of nonsense codons with exon skipping.

Mutation research - 1 Sept 1998

Valentine C R

Abstract excerpt

Some genes that contain premature nonsense codons express alternatively-spliced mRNA that has skipped the exon containing the nonsense codon. This paradoxical association of translation signals (nonsense codons) and RNA splicing has inspired numerous explanations. The first is based on the fact that premature nonsense codons often reduce mRNA abundance. The reduction in abundance of full-length mRNA then allows...

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PMID: 9806422
DOI: 10.1016/s1383-5742(98)00010-6

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